对抗世卫组织优先的真菌病原体的生物活性植物化合物的审查
Yohana Porto Calegari-Alves1, Renata Pereira Costa2, Camila Innocente-Alves1
1Post-Graduation Program in Cellular and Molecular Biology, Federal University of Rio Grande Do Sul - Porto Alegre, RS, 90610-000, Brazil; Laboratory of Molecular Microbiology and Proteomics, Faculty of Pharmacy, Federal University of Rio Grande Do Sul - Porto Alegre, RS, 90610-000, Brazil.
Microbial pathogenesis
|July 27, 2025
概括
植物化合物为对抗危险真菌提供了新的希望. 本综述强调了天然分子对世界卫生组织 (WHO) 优先的真菌病原体有效,包括耐药菌株,用于开发新型抗真菌疗法.
科学领域:
- 菌类学 菌类学是指菌类学.
- 药理学是指药理学,即药理学是指药理学.
- 自然产品化学 自然产品化学
背景情况:
- 世界卫生组织 (WHO) 在2022年确定了19种优先的真菌病原体,原因是治疗选择有限,药物耐药性增加.
- 病原性真菌对全球健康构成重大威胁,需要发现新的治疗策略.
- 植物衍生生物活性化合物被认为具有抗微生物潜力,包括对抗耐药性真菌菌株.
研究的目的:
- 编制和审查表现出抗真菌活性的植物衍生生物分子,以对抗世卫组织优先的真菌病原体.
- 发现基于天然产品的抗真菌研究中的知识缺口,特别是对于像Candida auris.这样的研究较少的病原体.
- 展示有希望的天然化合物作为开发新抗真菌药物的潜在途径.
主要方法:
- 系统性文献综述研究的研究调查植物衍生化合物对WHO优先的真菌病原体.
- 分析各种化学类别,包括黄类,类,类,类和精油.
- 报告的抗真菌活性的评估,包括对抗药物耐药性真菌菌株的有效性和与常规药物的协同作用.
主要成果:
- 在各种化学类别中,许多植物性化合物表现出显著的抗真菌活性.
- 有证据表明,天然化合物和现有的抗真菌药物之间有协同作用.
- 对一些病原体的研究,比如Cryptococcus neoformans,比对其他病原体的研究更广泛,比如Candida auris.
结论:
- 来自植物的生物活性化合物是开发新抗真菌疗法对抗世卫组织优先病原体的宝贵资源.
- 需要进一步的研究来探索天然产品的全部潜力,特别是对于尚未探索的真菌威胁.
- 天然化合物可能提供替代或补充治疗来对抗抗真菌药物耐药性.
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