双重环境压力因素:pH值如何调节丹尼奥里奥的抗生素毒性?
Bárbara S Diogo1, Sara Rodrigues2, Oksana Golovko3
1ICBAS, Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, Porto 4050-313, Portugal; CIMAR/CIIMAR LA, Centro Interdisciplinar de Investigação Marinha e Ambiental, Universidade do Porto, Terminal de Cruzeiros do Porto de Leixões, Matosinhos 4450-208, Portugal; FCUP, Departamento de Biologia, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre S/N, Porto 4169-007, Portugal.
Environmental toxicology and pharmacology
|July 27, 2025
概括
环境压力因素,如pH值变化和抗生素污染,会损害水生生物. 这项研究表明,硫甲醇和三甲胺的毒性如何随着pH值而变化,影响鱼类健康和生态系统.
科学领域:
- 环境科学 环境科学
- 生态毒理学 生态毒理学
- 水生生物学 水生生物学
背景情况:
- 水生生态系统面临来自pH值波动和抗生素污染的联合威胁.
- 通过改变电离和膜透性,pH会影响抗生素毒性,药理动力学和药理动力学.
- 了解这些相互作用对于评估生态风险至关重要.
研究的目的:
- 为了评估硫甲醇 (SMX),三甲 (TRIM) 和它们的混合物 (MIX) 对丹尼奥雷里奥幼虫的毒性.
- 研究不同pH值 (6.5,7.5,9.0) 对抗生素毒性的影响.
- 评估对多种生物标志物的影响,包括氧化应激,新陈代谢和DNA损伤.
主要方法:
- 暴露的丹尼奥雷里奥幼虫暴露在SMX,TRIM和MIX的环境相关度中.
- 测试了三种pH值的毒性:酸性 (6.5),中性 (7.5) 和性 (9.0).
- 利用多种生物标志物的方法来评估生理和细胞健康.
主要成果:
- 硫甲醇 (SMX) 在酸性pH下显示出增加的毒性,导致氧化应激和DNA损伤.
- 在中性和性pH值下,trimethoprim (TRIM) 的毒性更高,影响抗氧化防御.
- 混合物在中性pH值下具有中度毒性,导致显著的生理干扰.
结论:
- 抗生素毒性和对水生生物的影响受到pH的强烈影响.
- 抗生素和pH值变化等联合压力因素对水生生态系统健康构成重大风险.
- 对多种压力因素的综合研究对于保护水生生物多样性免受气候变化和污染至关重要.
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