交感激活与暴露于挥发性有机化合物的关联:一个横截面研究
Cameron K Stopforth1, Clara Sears2, Hong Gao2
1Christina Lee Brown Envirome Institute, School of Medicine, University of Louisville, 302 E Muhammad Ali Blvd, Louisville, KY, 40202, USA; Department of Physiology, School of Medicine, University of Louisville, 500 S. Preston St, Louisville, KY, 40202, USA.
Environmental research
|July 27, 2025
概括
易挥发性有机化合物 (VOC) 暴露与交感神经系统激活的增加有关,可能导致不良健康影响. 这项研究发现,较高的VOC代谢物水平与尿液中单胺度升高有关.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 心血管健康 心血管健康
背景情况:
- 挥发性有机化合物 (VOC) 是广泛存在的空气污染物,与心脏代谢问题有关.
- 连接VOC暴露与健康结果的机制尚不清楚.
- 这项研究研究了VOC暴露与交感神经系统激活之间的关联.
研究的目的:
- 评估暴露于挥发性有机化合物 (VOC) 和交感激活之间的关系.
- 为了识别与同情性标记物相关的特定VOC代谢物.
- 探索同情语调在VOC相关心脏代谢效应中的作用.
主要方法:
- 从696名参与者 (年龄在25-70岁) 的尿液样本中,使用UPLC-MS/MS.分析了VOC和单胺代谢物.
- 用多变量线性回归和基于量子的g计算来评估关联.
- 模型根据人口统计,压力,吸烟,药物和尿液收集时间进行了调整.
主要成果:
- 尿液中较高的VOC代谢物水平与尿液中单胺度的增加相关.
- 挥发性有机化合物代谢物混合物的四分位数增加与血清素和上腺素的显著增加有关.
- 特定的VOC代谢物,包括来自N,N-二甲基形式胺和1,3-丁二烯的代谢物,与同情性标记物有着强大的关联.
结论:
- 挥发性有机化合物暴露与同情激活的升高有关.
- 交感性过活性可能会调解VOCs带来的负面心脏代谢结果.
- 针对VOC暴露可以减轻相关的心血管风险.
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