深层神经元补偿在新皮质发育中的第4层感觉受体细胞的损失
Pei-Shan Hou1, Carina Hanashima2
1Institute of Anatomy and Cell Biology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Institute of Brain Science, College of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan; Brain Research Center, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan; Laboratory for Developmental Biology, Department of Biology, Faculty of Education and Integrated Arts and Sciences, Waseda University, Tokyo 162-8480, Japan; Laboratory for Neocortical Development, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan.
皮层神经元的发育显示了可塑性. 第4层神经元的早期损失促使深层神经元采用第4层的身份,保持大脑电路的形成.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 皮层发育 皮层发育
背景情况:
- 第4层皮质神经元对于通过thalamocortical输入进行感官处理至关重要.
- 第四层神经元身份的固定性尚未完全理解.
- 了解细胞命运可塑性是理解大脑发育的关键.
研究的目的:
- 为了研究皮层神经元的可塑性.
- 为了确定4层神经元的身份是固定的还是可以改变.
- 探索皮层发育中的补偿机制.
主要方法:
- 利用他莫西芬可诱导的条件除来消除第4层注定的神经元.
- 采用出生日期标记和分子分析来追踪细胞命运.
- 研究的基因表达变化,包括Foxg1和Nr2f1.1.
主要成果:
- 早期4层神经元的枯竭并没有消除4层人口.
- 早些时候出生的深层神经元通过采用4层身份来补偿.
- 这种命运转变涉及Foxg1下调和Nr2f1上调.
结论:
- 皮层神经元的命运表现出可塑性,特别是在应对早期细胞损失时.
- 一个涉及Foxg1和Nr2f1的分子开关调节了自适应神经发生.
- 大脑有补偿机制来维持皮质电路完整性,尽管神经元损失.
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