塞夫托比普罗尔对各种遗传类型的抗甲素耐药黄金葡萄球菌的活性
Marisa L Winkler1, John H Kimbrough1, Helio S Sader1
1Element Iowa City (JMI Laboratories), North Liberty, IA, USA.
Journal of global antimicrobial resistance
|July 27, 2025
概括
塞夫托比普罗尔对抗抗甲素耐药黄金葡萄球菌 (MRSA) 血流感染具有很高的活性,其性能优于塞夫塔罗林. 这使得 ceftobiprole成为治疗MRSA感染的潜在首选.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 塞夫托比普罗尔被批准用于治疗肺炎,皮肤感染和金黄色葡萄球菌血流感染.
- 甲素耐药的金黄色细菌 (MRSA) 呈现出多样化的血统,具有不同的耐药性和毒性因子.
研究的目的:
- 为了评估 ceftobiprole 对当代MRSA从血液感染中分离的体外活性.
- 为了比较 ceftobiprole 与其他抗菌剂 (包括 ceftaroline) 的疗效.
主要方法:
- 使用微稀释的抗微生物敏感性测试对来自血液感染的150个MRSA分离物 (2018-2019) 进行了抗微生物敏感性测试.
- 根据美国FDA,CLSI和EUCAST指南解释结果.
- 基因组测序以确定多位置序列,克隆复合体 (CC),spa和SCCmec类型用于克隆分组.
主要成果:
- 塞夫托比普罗尔对MRSA分离物的敏感率高 (97.3%),超过了塞夫塔罗林 (85.3%).
- 塞夫托比对主要的MRSA克隆群 (CC5,CC8,CC22) 保持了显著的活性.
- 仅有2.7%的分离物对塞夫托比普罗尔不敏感,相比之下,塞夫塔罗林的比例为14.7%,耐药性与特定的MRSA血统有关.
结论:
- 与Ceftaroline相比,Ceftobiprole在体外表现出优异的活性,针对各种MRSA分离物的集合.
- 由于其增强的疗效,Ceftobiprole可能是治疗MRSA感染的首选宽谱抗菌药物.
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