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Updated: Sep 13, 2025

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
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在利多卡因活性药物成分和药物产品中形成尼托拉胺

Andrea Kalauz1, Sarolta Boglárka Szabó1, Adrienn Tóth-Malik1

  • 1Drug Substance Analytical Development Division, Egis Pharmaceuticals PLC, Keresztúri út 30-38, H-1106 Budapest, Hungary.

Journal of pharmaceutical sciences
|July 27, 2025
PubMed
概括

利多卡因药物中N-尼托拉胺的形成与助剂中的高温和酸盐有关. 利多卡因降解为前体,形成N-尼特罗斯乙烯胺 (NDEA) 和N-尼特罗斯甲基利多卡因.

关键词:
药物制品 药物制品 药物制品基因毒性/变异性杂质的杂质.利多卡因 (Lidocaine) 是一种药物.这是一种N-nitroso-desethyl利多卡因.这是一种N-nitrosodiethylamine.亚胺酸盐的含量是多少

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