组织学等级在新辅助剂治疗的乳腺癌中具有临床有效性:一个多中心研究
Sanna Steen1, Constance Boissin2, Mattias Rantalainen3
1Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden.
概括
组织学瘤等级预测了接受新辅助治疗的乳腺癌患者的结果. 治疗后的瘤等级是整体生存的关键预后因素,有助于治疗决策.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 组织学等级是乳腺癌的强有力的预后因素.
- 它在新辅助剂环境中的临床有效性需要进一步调查.
研究的目的:
- 评估组织学等级在接受新辅助治疗的乳腺癌患者的预后意义.
- 在后neoadjuvant设置中评估瘤等级和整体存活率 (OS) 之间的关联.
主要方法:
- 分析了507名接受新辅助药治疗的乳腺癌患者的多中心队列.
- 在术前活检和切割样本中评估了瘤等级,与297名初级手术对照人群相比.
- 卡普兰-梅尔分析,日志等级测试和多变量考克斯回归被用于生存分析.
主要成果:
- 从活检到切除,瘤等级的降低在新辅助者队列 (29.8%) 比对照组 (5.7%) 更常见.
- 在活检和切除中,高度瘤与明显更差的预后有关 (P < .001).
- 切除标本中的后辅助等级独立预测了OS (HR,2.09;P = .002),而不是活检等级 (HR,1.40;P = .14).
- 级别是ER+/HER2-亚型的预后 (P <.001).
结论:
- 组织学瘤等级与新辅助治疗后患者的治疗结果显著相关.
- 切除标本中的后辅助性瘤等级是整体存活时间的独立预后标记.
- 在新辅助疗法后组织学等级评估可以为治疗决策提供信息.
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