由国际旅行引发的肠道和口腔微生物群组成的变化
G Kurlberg1, Y Wettergren1,2
1Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Beneficial microbes
|July 27, 2025
概括
国际旅行显著改变了人类的肠道和口腔微生物群. 在前往尼泊尔后观察到埃舍里奇亚-希格拉菌和口腔细菌的变化,可能作为结直肠癌风险标志物.
科学领域:
- 微生物组研究的研究.
- 人类的微生物群.
- 旅行医药 旅行医药
背景情况:
- 在发展中国家,结肠直肠癌 (CRC) 的发病率正在增加.
- 人类微生物群的组成受到饮食,生活方式和旅行的影响.
- 国际旅行可以引起肠道和口腔微生物群落的显著改变.
研究的目的:
- 在尼泊尔逗留两个月后,调查瑞典居民肠道和口腔微生物群的变化.
- 评估这些微生物变化的性质,程度和速度.
- 确定微生物群变化与结直肠癌 (CRC) 风险之间的潜在联系.
主要方法:
- 在旅行前,旅行后以及返回瑞典后两周和四周,从8名参与者收集便和唾液样本.
- 使用Illumina MiSeq平台对16SrRNA基因的V3-V4区域进行深度测序.
- 微生物群分析使用DADA2进行排斥,并使用SILVA进行分类注释.
主要成果:
- 在尼泊尔逗留后的所有旅行者中观察到肠道Escherichia-Shigella丰度的显著增加.
- 在返回瑞典四周后,在50%的参与者中,Escherichia-Shigella持续存在.
- 在尼泊尔逗留后,观察到口腔Fusobacteriaceae和Campylobacteraceae的减少.
结论:
- 国际旅行会导致人类微生物组的实质性和可测量的改变.
- 这些旅行引起的微生物群变化可以作为结直肠癌 (CRC) 风险评估的潜在生物标志物.
- 微生物组研究必须考虑国际旅行对微生物组成的影响.
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