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Updated: Sep 13, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

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广泛的3' UTR拼接通过多种机制调节瘤基因转录的表达

Jack J Riley1, Cristina N Alexandru-Crivac1, Sam Bryce-Smith1

  • 1Sheffield Institute for Nucleic Acids, School of Biosciences, The University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, United Kingdom.

Nucleic acids research
|July 27, 2025
PubMed
概括

在3'未翻译区域 (3' UTRs) 进行剪接是常见的,即使在癌症中也是如此. 这种3' UTR 内子拼接可以调节基因表达,避免像无意中介衰变 (NMD) 这样的降解途径.

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