肠道微生物群对双醇的转化:对物种特定途径和毒性影响的洞察
Meilin Lv1,2, Shiqun Chen3, Hua Qin1,2
1College of Sciences, Northeastern University, Shenyang 110819, China.
人体肠道细菌将双A-甘油甲基酸盐 (Bis-GMA) 转化为毒性较小的产品. 肠道微生物群对环境污染物的这种微生物转化显著影响了它们的毒性和健康影响.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 毒理学 毒理学 毒理学
背景情况:
- 双 (BPs) 在消费品中广泛使用,引发了对环境持久性和健康风险的担忧.
- 肠道微生物群在体内BP的代谢和转化中起着关键作用,影响其毒理结果.
- 关于肠道微生物群对BP转化的研究是有限的,需要进一步调查.
研究的目的:
- 为了研究人类肠道细菌菌株在体外转化21 bisphenols.
- 识别双转化产物 (TPs) 并评估它们的毒性.
- 阐明肠道微生物群在调节环境污染物的毒性中的作用.
主要方法:
- 在体外化21种双醇与6种人类肠道细菌菌株的化.
- 使用分析技术识别转化产品.
- 在体内确认转化途径.
- 细胞毒性测定和人类肠道有机体模型,以评估生物效应.
主要成果:
- 双甲-甘甲烯酸盐 (Bis-GMA) 被多种细菌菌株显著转化,产生了八种特定物种的TP (例如,乙化,化,棕化产品).
- 在体内研究证实了Bis-GMA转化为 bisphenol A bis (2,3-dihydroxypropyl) 以太 (Bis-HPPP),在体内被确定.
- 与Bis-GMA相比,Bis-HPPP的细胞毒性较低,对人类肠道器官功能造成的损害不那么严重.
结论:
- 人的肠道细菌可以将双甲糖醇甲基酸盐 (Bis-GMA) 转化为各种特定物种的产品.
- 微生物转化显著调节双的毒性,比斯-HPPP的细胞毒性低于比斯-GMA.
- 肠道微生物群在环境污染物如双的排毒中发挥着至关重要的作用.
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