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Updated: Sep 13, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

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一个共价自我报告的降解剂可实时监测向蛋白质降解

Wei Zhang1, Lizhen Yuan1, Rui Liu1

  • 1State Key Laboratory of Geomicrobiology and Environmental Changes, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China.

Journal of the American Chemical Society
|July 28, 2025
PubMed
概括

我们开发了一种共价自报告降解剂 (Co-SPeD),用于实时监测蛋白质降解. 这种的治疗平台显示出显著的抗瘤功效,并指导癌症治疗的优化.

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Regulated Protein Degradation02:58

Regulated Protein Degradation

It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
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