Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

Osmoregulation in Insects

Osmoregulation in Insects

Malpighian tubules are specialized structures found in the digestive systems of many arthropods, including most insects, that handle excretion and osmoregulation. The tubules are typically arranged in pairs and have a convoluted structure that increases their surface area.

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Evidence Map Analysis on Randomized Controlled Trials: Chinese Patent Medicines and Classic Traditional Chinese Medicine Prescriptions.

Journal of evidence-based medicine·2026

Same author

DCAF13 is associated with pancreatic ductal adenocarcinoma progression and p53-related signaling in TP53-mutant cells.

Biochemical and biophysical research communications·2026

Same author

YIF1A activates mTORC1 signaling to promote cellular senescence.

Cell death & disease·2026

Same author

A study on risk prediction of decline in self-care ability one month after discharge in postoperative colorectal cancer patients based on routine clinical indicators.

Frontiers in surgery·2026

Same author

SERS Facemask for Rapid and Portable Sensing Mycobacterium Tuberculosis Antigens for TB Screening.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Efficacy and Implementation of a Theory-Underpinning Needs-Oriented mHealth Supportive Program for Family Caregivers of Community-Dwelling Frail Older Adults (Hi-Care): A Randomized Controlled Trial.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2026

Search research articles

相关实验视频

Updated: Jun 23, 2026

Multi-unit Recording Methods to Characterize Neural Activity in the Locust Schistocerca Americana Olfactory Circuits

Multi-unit Recording Methods to Characterize Neural Activity in the Locust Schistocerca Americana Olfactory Circuits

Published on: January 25, 2013

在迁徙的虫中,R-loop调节了以气味为导向的行为.

Jipeng Liu^1,2, Lihan Zhao¹, Jiaqi Yu¹

¹College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.

|July 28, 2025

概括

过度的R环,可以损害基因组稳定的结构,破坏虫的嗅觉反应. 酶RNase H1 (RNH1) 解决了这些R循环,其缺乏导致嗅觉丧失.

科学领域:

神经科学是一个神经科学.
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

R-循环 (DNA:RNA杂交) 与神经退行性疾病和基因组不稳定性有关.
嗅觉功能障碍是神经退行性疾病的早期症状,但R环在嗅觉中的作用尚不清楚.
迁徙虫对同类和植物有嗅觉反应,这使它们成为一个合适的模型.

研究的目的:

研究R环在迁徙的中枢神经系统中调节嗅觉中的功能.
确定RNase H1 (RNH1) 在解决R循环中的作用及其对嗅觉行为的影响.

主要方法:

免疫光分析以检测虫天线和大脑中的R环和RNH1表达.
通过RNA干扰 (RNAi) 来降低RNH1的表达.
行为测试用于评估对气味剂的嗅觉反应.
对DNA损伤和新生RNA合成的评估.

主要成果:

在的天线和大脑中存在R环和RNH1,特别是在体和天线叶中.
抑制RNH1导致嗅觉反应丧失,但不影响运动或身体颜色.
缺少RNH1导致R-循环水平增加,DNA损伤,以及大脑中新生的RNA合成减少.

关键词:

在RNase H1中.在R-loop中使用R-loop.迁徙的虫是迁徙的虫.嗅觉嗅觉是一种嗅觉.

更多相关视频

Localization of Odorant Receptor Genes in Locust Antennae by RNA In Situ Hybridization

Localization of Odorant Receptor Genes in Locust Antennae by RNA In Situ Hybridization

Published on: July 13, 2017

Single Sensillum Recordings for Locust Palp Sensilla Basiconica

Single Sensillum Recordings for Locust Palp Sensilla Basiconica

Published on: June 23, 2018

相关实验视频

Last Updated: Jun 23, 2026

Multi-unit Recording Methods to Characterize Neural Activity in the Locust Schistocerca Americana Olfactory Circuits

Multi-unit Recording Methods to Characterize Neural Activity in the Locust Schistocerca Americana Olfactory Circuits

Published on: January 25, 2013

Localization of Odorant Receptor Genes in Locust Antennae by RNA In Situ Hybridization

Localization of Odorant Receptor Genes in Locust Antennae by RNA In Situ Hybridization

Published on: July 13, 2017

Single Sensillum Recordings for Locust Palp Sensilla Basiconica

Single Sensillum Recordings for Locust Palp Sensilla Basiconica

Published on: June 23, 2018

结论:

由于RNH1缺乏而增加的R环水平可能导致虫失去嗅觉反应.
这项研究首次证明了RNH1介导的R循环分辨率在嗅觉行为调节中的参与.
这些发现为R环在调节嗅觉中的作用以及对神经退行性疾病的潜在影响提供了新的见解.