父亲表达的基因10促进剂甲基化水平作为慢性乙型肝炎B患者HBeAg血清转化预测剂

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¹Department of Hepatology, Qilu Hospital of Shandong University, Jinan, Shandong Province, PR China.

Journal of medical virology

|July 28, 2025

概括

父性表达的基因10 (PEG10) 促进子甲基化是预测慢性乙型肝炎 (CHB) 患者中乙型肝炎e抗原血清转化 (HBeAg SC) 的有前途的生物标志物. 这一发现有助于开发用于更好的CHB管理的预测模型.

科学领域:

肝病学肝病学是一种肝病学.
分子生物学分子生物学
生物标志物发现发现

背景情况:

慢性乙型肝炎 (CHB) 管理面临的挑战是抗病毒反应和预测生物标志物.
确定可靠的乙型肝炎抗原血清转化 (HBeAg SC) 生物标志物对于治疗疗效至关重要.

研究的目的:

调查父亲表达的基因10 (PEG10) 在HBeAg SC.中的作用.
探索PEG10作为一种潜在的治疗标和CHB中的预测生物标志物.

主要方法:

机器学习算法 (BORUTA,RF,LASSO) 选了349名参与者的关键基因.
在141名HBeAg阳性患者中分析了PEG10 mRNA,促进物甲基化和血水平.
使用后勤回归和名图来评估PEG10的影响,并预测HBeAg SC.

主要成果:

阳性HBeAg患者显示PEG10mRNA显著升高,PEG10促进体甲基化减少.
PEG10 mRNA水平与HBV DNA,HBeAg和HBsAg有很强的相关性.
PEG10促进物甲基化是HBeAg SC的独立预测因子,预测性名谱达到0.895.89的AUC.

结论:

PEG10促进体甲基化状态是预测CHB患者HBeAg SC的一个有希望的生物标志物.
作为治疗目标和CHB管理中的预测标记,PEG10值得进一步研究.

关键词:

现在,CHB已经成为了CHB.通过DNA甲基化.这就是HBeAg SC.在PEG10的基础上,PEG10 机器学习是机器学习.

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