肠道微生物群在没有抗抑郁药的抑郁患者中发生变化,与抑郁症的严重程度有关
Sofia Cussotto1, Romain Colle2,3, Cosmin S Voican4,5,6
1Université Paris-Saclay, UVSQ, Centre de Recherche en Epidémiologie et Santé Des Populations (CESP), UMR 1018, CESP-Inserm, Team Moods, Faculté de Pharmacie, Orsay, France.
Journal of neurochemistry
|July 28, 2025
概括
与健康对照人群相比,患有严重抑郁症 (MDD) 的患者表现出肠道微生物群组成的改变,包括Lachnospiraceae和Bifidobacteriaceae的变化. 特定的微生物减少与抑郁症严重程度的增加相关,这表明肠道微生物群是潜在的治疗目标.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 微生物群-肠-大脑轴正受到越来越多的关注,但其在主要抑郁症 (MDD) 中的作用尚不清楚.
- 关于肠道微生物群和MDD的现有数据稀缺且不一致,特别是在症状严重程度和治疗反应方面.
研究的目的:
- 描述无抗抑郁药的MDD患者的肠道微生物群,这些患者目前有重大抑郁发作 (MDE).
- 为了比较MDE患者和健康对照 (HCs) 之间的肠道微生物组成.
- 调查肠道微生物群组成和抑郁症严重程度之间的关联.
主要方法:
- 在25名没有抗抑郁药的MDE患者和28名HC患者中,使用16SrRNA测序分析了便微生物群组成.
- 抑郁症的严重程度使用汉密尔顿抑郁症评分尺度 (HDRS) 和临床全球印象 (CGI) 尺度进行评估.
- 进行了α和β多样性分析,以及对种群的差异丰度测试.
主要成果:
- 在MDE患者和HC患者之间没有观察到α多样性的显著差异.
- 在MDE患者中检测到包括Lachnospiraceae和Bifidobacteriaceae在内的类型的相对丰度的变化.
- 贝塔多样性分析揭示了不同的微生物群,与较高的抑郁症严重程度相关的Lachnospiraceae NK4A136属的减少.
结论:
- 与HC相比,没有抗抑郁药的MDE患者表现出明显的肠道微生物群变化.
- 特定的微生物变化,特别是Lachnospiraceae NK4A136的减少,与MDD的症状严重程度有关.
- 肠道微生物群可能是管理MDD的新型治疗点.
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