全球战略和行动消除HBV感染
Chih-Lin Lin1,2, Jia-Horng Kao3,4,5,6
1Department of Gastroenterology, Renai branch, Taipei City Hospital, Taipei, Taiwan.
Clinical and molecular hepatology
|July 28, 2025
概括
乙型肝炎疫苗接种和抗病毒治疗降低了HBsAg血清流行率和与HBV相关的肝癌. 新型生物标志物和疗法是实现消除乙型肝炎的最终目标的关键.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 乙型肝炎病毒 (HBV) 感染仍然是一个全球性的健康挑战,尽管几十年的疫苗接种和抗病毒疗法.
- 在接种疫苗的几代人中,HBsAg血清流行率和与HBV相关的肝细胞癌 (HCC) 发病率显著下降.
- 然而,完全消除HBV仍然难以捉摸,需要先进的策略.
研究的目的:
- 审查全球消除HBV的战略和倡议.
- 讨论新生物标志物和新兴疗法在实现HBV治愈中的作用.
- 概述未来的HBV根除行动计划.
主要方法:
- 这篇叙事综述综合了有关HBV流行病学,诊断和治疗的当前文献.
- 它研究了疫苗接种和抗病毒治疗对HBV感染和HCC的影响.
- 该审查分析了用于治疗和管理HBV的新生物标志物和研究药物.
主要成果:
- 定量HBsAg,HBcrAg和HBVRNA在预测疾病进展和功能治愈方面表现有前途.
- 目前的治疗方法 (NA,基化干扰素) 减少慢性乙型肝炎 (CHB) 患者的HCC发生率和复发.
- 新兴的直接作用抗病毒药物和向宿主药物旨在通过向病毒生命周期和增强免疫力来治愈HBV.
结论:
- 实现HBV消除需要采取多方面的方法,包括普遍查,简化早期治疗和精确的终身管理.
- 新型生物标志物和治疗剂对于进展到功能治疗和最终消除HBV至关重要.
- 持续的全球合作和实施战略行动计划对于消除乙型肝炎感染至关重要.
更多相关视频
11:34A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
Published on: May 10, 2022
2.3K
09:35Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
Published on: February 1, 2017
13.4K
相关概念视频
01:22Healthcare Associated Infections II: Preventive Measures
2.8K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.8K
01:26Standard Precaution
2.2K
Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
2.2K
01:28International Nursing Organizations II
1.1K
The World Health Organization (WHO) is a specialized agency of the United Nations based in Geneva. The WHO has many initiatives that center around health. Primarily, they lead global efforts to expand universal health coverage using science-based policies and programs. They are also responsible for shaping health research agendas and developing norms and standards.
The WHO provides expert team support, including funding, vaccines, testing, and treatment tools at the country level to fight...
The WHO provides expert team support, including funding, vaccines, testing, and treatment tools at the country level to fight...
1.1K
01:26Levels of Health Promotion and Illness Prevention
13.3K
Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
In primary prevention, actions taken before disease onset prevent the disease from...
13.3K
01:26Methods Of Healthcare Delivery System
3.5K
At the different levels of the healthcare system, we see varying methods of healthcare used. These methods include managed care systems, case management, and primary healthcare.
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
Managed Care System:
The managed care system is designed to control the cost while maintaining the quality of care. The patient's care from admission to discharge is planned by the primary care provider or the case manager, also known as the gatekeeper. In a managed care system, the number of care providers is...
3.5K
01:10Retrovirus Life Cycles
46.9K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
46.9K