加拿大成人疫苗接种增加疹风险:多学科小组共识共识的见解
Wayne Ghesquière1, Dominique Tessier2, Vivien Brown3
1Island Health Authority, Division of Infectious Diseases, Clinical Assistant Professor of Medicine, University of British Columbia, Victoria, BC, Canada.
Expert review of vaccines
|July 28, 2025
概括
重组疹疫苗 (RZV) 应提供给所有年龄在18岁及以上,患疹风险增加的成年人. 这份共识指南有助于临床医生在免疫受损患者和患有慢性疾病的人员接种HZ疫苗.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 疹疹 (HZ) 的风险随着年龄 (≥50岁) 和免疫力低下的人增加.
- 在加拿大,复合性疹疫苗 (RZV) 已为50岁以上的成年人建立.
- 2021年,RZV授权范围扩大,包括因免疫缺陷或免疫抑制而面临风险增加的18岁以上的个人,从而造成了临床不确定性.
研究的目的:
- 在加拿大制定基于共识的指导方针,用于加拿大18岁以上的高风险成年人使用RZV.
- 为解决针对特定患者群体的RZV疫苗接种的临床不确定性.
主要方法:
- 加拿大多学科专家小组召开会议,制定指导方针.
- 使用了共识方法,定义为≥75%的专家一致意见.
- 该指南重点关注RZV在18岁以上的成年人中使用,因为他们有增加的HZ风险.
主要成果:
- 应向所有因疾病或治疗而增加HZ风险的18岁以上的个人提供RZV.
- 这包括患有慢性疾病 (例如,COPD,糖尿病) 增加HZ风险的个体.
- 个性化患者评估和共享决策至关重要;两剂量系列应及时给予.
结论:
- 专家的共识为18岁以上的个体增加HZ风险的RZV使用提供了指导.
- 这些建议补充了针对免疫功能低下患者的最新国家指南.
- 该指南旨在提高在风险人群中的疫苗接种率和HZ预防.
相关概念视频
01:51Vaccinations
45.3K
Overview
45.3K
01:30Cancer Vaccines
514
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
514
01:26Factors Affecting the Risk of Infection
12.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.3K
01:23Immunological Memory
5.2K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
5.2K
01:22Development of Immunocompetence
449
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
449
01:22Healthcare Associated Infections II: Preventive Measures
2.8K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.8K