处方安非他胺衍生物的药物短缺问题
Mana Sheykhsoltan1, Joshua Drobina2, Michele M Burns3
1Georgetown University School of Medicine (MS, MMA), Washington, DC.
概括
最近对安非他胺衍生物的药物短缺增加了,这是首线ADHD治疗. 这些短缺影响了儿童和青少年获得必需药物的机会.
科学领域:
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
- 儿科 儿科 儿科
背景情况:
- 胺衍生物是注意力缺陷/多动障碍 (ADHD) 的主要治疗方法.
- 最近的趋势表明,影响这些必需药物的药物短缺正在增加.
- 本研究调查了这些短缺的模式和特征.
研究的目的:
- 分析药物短缺影响处方安非他命衍生物的趋势.
- 确定特定的产品,配方和与这些短缺相关的原因.
- 了解安非他胺衍生品短缺的持续时间和单一来源状态.
主要方法:
- 利用了犹他大学药物信息服务 (UUDIS) 的数据,从2001年1月到2023年12月.
- 分析了各种安非他胺衍生物和配方 (口服,透皮) 报告的短缺情况.
- 检查了短缺趋势,产品细节,原因,持续时间和制造商状态.
主要成果:
- 在2001年至2023年期间,共记录了26起影响安非他胺衍生物的短缺情况.
- 短缺峰值年包括2012年,2013年,2015年和2023年,每年有7次短缺.
- 解决的短缺平均为20.7个月,其中甲基胺延长释放片的短缺时间最长 (61.6个月).
结论:
- 氨基胺衍生物的短缺正在增加,限制了对关键的多动症治疗方法的获取.
- 访问有限可能会对儿科患者的认知发展和心理健康产生负面影响.
- 解决这些缺陷对于确保ADHD患者的护理连续性至关重要.
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