儿科中的梅罗烯姆/瓦博巴克坦:CRE腹腔内感染的2例
Ugene Sano1, Rachel Meyers1,2, Uzma Hasan1
1Departments of Pharmacy (US, RM, SS) and Pediatric Infectious Disease (UH), Cooperman Barnabas Medical Center, Livingston, NJ.
概括
梅罗胺/瓦博巴克坦在两名患有耐卡巴胺抗性肠细菌 (CRE) 腹腔的儿科患者中显示出安全有效的使用. 需要进一步的研究来确定儿科患者的最佳使用和安全性.
科学领域:
- 传染性疾病 传染性疾病
- 儿科药理学 儿科药理学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 梅罗烯姆/瓦博巴克坦是一种用于广泛抗药性感染的抗生素组合.
- 已被批准用于成人复杂的尿路感染,儿科数据有限.
- 耐卡巴胺的肠道细菌 (CRE) 构成了严重的治疗挑战.
研究的目的:
- 描述梅罗尼姆/瓦博巴克坦在患有CRE感染的儿科患者的使用情况.
- 评估梅罗烯姆/瓦博巴克坦在这个人群中的安全性和有效性.
主要方法:
- 一系列病例涉及两名儿科患者 (11岁和15岁).
- 患者呈现出由CRE引起的腹腔内.
- 治疗包括使用美罗烯姆/瓦博巴克坦.
主要成果:
- 这两位儿科患者都经历了临床改善.
- 在完成抗生素疗程后的随访期间没有报告任何并发症.
- 在这些病例中,美罗烯姆/瓦博巴克坦被证明是安全有效的治疗方法.
结论:
- 梅罗烯姆/瓦博巴克坦可以安全有效地用于儿科患者治疗CRE感染.
- 需要额外的数据来确定儿科患者的最佳使用和安全性.
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