辅助性横直流刺激用于精神分裂症认知改善:从系统性审查和探索性元分析的见解
Gaolei Yao1,2, Yuan Huang3, Junjiao Ping2
1Clinical Research and Big Data Laboratory, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China.
Frontiers in psychiatry
|July 28, 2025
概括
跨直流刺激 (tDCS) 在改善精神分裂症患者的认知功能和减少症状严重程度方面显示出有前途. 这一系统性审查和元分析支持tDCS作为一种潜在的非药物治疗选择.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床试验 临床试验
背景情况:
- 精神分裂症是一种复杂的精神障碍,具有显著的认知和功能障碍.
- 目前对精神分裂症的治疗有局限性,需要探索新的治疗方法.
研究的目的:
- 系统地审查和元分析跨直流刺激 (tDCS) 作为精神分裂症辅助治疗的临床疗效.
- 评估tDCS对精神分裂症患者认知功能和疾病严重程度的影响.
主要方法:
- 在PubMed,Embase和Web of Science进行了随机对照试验 (RCT) 的系统搜索.
- 包括11个符合条件的RCT,并提取数据进行元分析,包括出版偏差和敏感性分析.
- 使用RevMan软件 (版本5.4) 进行了统计分析.
主要成果:
- 辅助的tDCS显著增强了精神分裂症患者的认知功能 (SMD = 3.57,P < 0.00001).
- 亚组分析表明,每天15次或两次服用tDCS可降低疾病严重程度 (SMD分别为-0.56和-0.85).
结论:
- 超直流刺激 (tDCS) 显示出作为一种有效的辅助疗法的潜力,可以改善认知功能并减少精神分裂症症状的严重程度.
- tDCS可能是精神分裂症的有价值的非药物治疗选择,需要进一步调查,并可能被纳入临床指南.
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