肺功能变化和结缔组织生长因子表达在异常性肺纤维化,其他渐进性纤维化间歇性肺病和后COVID纤维化
Elene Sherozia1,2, Clive Page3, Tamuna Kakhniashvili4
1Internal Medicine, David Tvildiani Medical University, Tbilisi, GEO.
Cureus
|July 28, 2025
概括
结缔组织生长因子 (CTGF) 水平与异常性肺纤维化 (IPF) 和其他渐进性纤维化间歇性肺病 (F-ILDs) 的肺功能下降相关. 在这些情况下,CTGF可以作为纤维化进展的生物标志物.
科学领域:
- 肺部病理学 肺部病理学
- 生物化学 生物化学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 异形性肺纤维化 (IPF) 和其他渐进性纤维化间歇性肺病 (F-ILDs) 的临床过程有变化,需要改进的诊断和预后工具.
- 在IPF中观察到血连接组织生长因子 (CTGF) 的升高,并与强迫生命能力 (FVC) 的变化有关.
研究的目的:
- 调查F-ILD患者 (包括IPF,其他F-ILD和COVID-19后病例) 的结合组织生长因子 (CTGF) 水平.
- 在12个月内评估CTGF水平与肺功能变化 (FVC,DLCO) 之间的关联.
主要方法:
- 一项前性队列研究,涉及86名受试者超过30个月,涉及18个月的参与期和12个月的观察期.
- 在基线和研究结束时评估强迫生命能力 (FVC),扩散一氧化碳的肺容量 (DLCO) 和血清CTGF水平 (ELISA).
主要成果:
- 在整体F-ILDs组,IPF,iNSIP和慢性sarcoidosis亚组中,在血清CTGF水平的变化和FVC和DLCO的变化之间发现了显著的负相关性.
- 在COVID-19后组中,CTGF水平和肺功能变化之间没有明显的相关性.
结论:
- 增加的CTGF水平与IPF和其他渐进性纤维化肺病的肺功能下降相关,这表明CTGF是纤维化进展的潜在生物标志物.
- 后COVID-19纤维化可能代表一个非进展性纤维化疾病,需要进一步调查.
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