相关实验视频
Updated: Sep 13, 2025

08:50
Predictive Immune Modeling of Solid Tumors
Published on: February 25, 2020
7.1K
癌症免疫治疗中的预测生物标志物:在选择的固体瘤中进行叙述性审查
Mehak Puntambekar1, Neville Shery2, Ishaan Parokkaran3
1Medicine and Surgery, Pilgrim Hospital, United Lincolnshire Hospitals National Health Service (NHS) Trust, Boston, GBR.
Cureus
|July 28, 2025
概括
癌症免疫疗法显示有前途,但患者的反应各不相同. 本综述检查了PD-L1和MSI-H等关键生物标志物,以及新兴的标志物,以改善肺癌,黑色素瘤,乳腺癌和结直肠癌的治疗预测.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 癌症免疫疗法彻底改变了癌症治疗,在一些患者中产生了持久的反应.
- 可变的响应率凸显了对可靠的预测和预后生物标志物的急需.
研究的目的:
- 对指导非小细胞肺癌,黑色素瘤,乳腺癌和结直肠癌免疫治疗的生物标志物的证据进行审查和综合.
- 为了实践,现实世界的应用,比较验证和新兴的生物标志物.
主要方法:
- 从PubMed和Scopus对2025年5月的文献进行叙事审查.
- 包含与免疫疗法生物标志物相关的关键术语,没有日期限制.
- 相关研究的手动选.
主要成果:
- 临床验证的生物标志物,如编程死亡连接物1 (PD-L1) 和微卫星不稳定性高 (MSI-H) 是有用的,但有局限性 (试验可变性,瘤异质性).
- 新兴的生物标志物,如瘤透淋巴细胞 (TIL),相对乙素计数 (REC),乳酸脱酶 (LDH) 和S100结合蛋白B (S100B) 显示出潜力,但需要进一步验证.
- 介绍了不同癌症类型的生物标志物的整合和比较.
结论:
- 生物标志物对于优化癌症免疫治疗疗效和患者选择至关重要.
- 虽然PD-L1和MSI-H等已知标志物是有价值的,但对新生物标志物的持续研究对于改善治疗结果至关重要.
- 为了使新兴生物标志物的广泛临床采用,需要进一步的验证和标准化.
相关概念视频
Tumor Immunotherapy
662
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
662
Cancer Vaccines
514
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
514
Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
Combination Therapies and Personalized Medicine
5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
Cancer Therapies
8.0K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.0K

