从饮食和补充剂摄入的与糖尿病病风险之间的L形非线性关系:一个横截面研究
Jia Du1, Xuetong Zhu1, Ze Li1
1Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, China.
Frontiers in nutrition
|July 28, 2025
概括
更高的摄入量与糖尿病病 (DN) 的风险降低有关. 确定了每天345毫克的门值,超过该门额外的并没有进一步降低DN风险.
科学领域:
- 营养科学 营养科学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
背景情况:
- 摄入量与糖尿病病 (DN) 之间的关系仍然存在争议.
- 从饮食和补充剂中调查总摄入量对于了解其在DN中的作用至关重要.
- 探索非线性剂量反应模式和值效应可以改进饮食建议.
研究的目的:
- 系统地评估总摄入量与糖尿病病 (DN) 风险之间的关联.
- 探索潜在的非线性剂量反应模式和摄入量对DN风险的值影响.
主要方法:
- 利用了国家健康和营养检查调查 (2007-2018) 的数据.
- 使用加权多变量后勤回归,受限立方线 (RCS) 和通用添加模型 (GAM) 来评估关联和非线性趋势.
- 使用分片回归来确定潜在的值,并进行子组分析.
主要成果:
- 包括3,355名参与者 (1,295名DN). 在DN组中,的摄入量较低 (300毫克/天对329毫克/天).
- 摄入量的每次SD增加都与19%的DN风险降低有关 (OR=0.81). 摄入量最高的四分位数显示风险降低了46% (OR=0.54).
- 观察到一个L形的非线性关联,在345毫克/天被确定为保护值. 在此以上,保护效果停滞不前.
结论:
- 总摄入量与糖尿病病 (DN) 风险相反相关.
- 鉴定出每天摄入345毫克的门值,低于这个门值,风险降低是显著的.
- 这些发现支持DN预防的摄入量建议,突出了其保护作用的潜在和点.
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