在热带新加坡的IgE介导子过敏
Lynette Liling Tan1, Si Hui Goh1, May Ping Lee1
1Allergy Service, Department of Paediatric Medicine, KK Women's and Children's Hospital, Singapore.
Asia Pacific allergy
|July 28, 2025
概括
子过敏是新加坡儿童显著的IgE介导食物过敏,经常出现皮肤反应和过敏反应. 这种过敏似乎是持久的,受影响个体的自然耐受性发展有限.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 儿科过敏 儿科过敏
- 食物过敏症 食物过敏症
背景情况:
- 子 (Cocos nucifera) 是一种热带水果,对过敏的文献记录有限.
- 在亚洲,一个子消费量高的地区,关于子过敏的数据很少.
- 通过IgE介导的子过敏尚未得到充分研究,特别是在儿童群体中.
研究的目的:
- 描述新加坡儿童IgE介导子过敏的人口统计和临床表现.
- 调查子过敏的临床特征和自然史.
- 在儿科队列中确定与子过敏相关的风险因素和结果.
主要方法:
- 对被诊断患有子过敏的儿科患者的回顾性审查.
- 研究期:2017-2022年,在新加坡的三级儿科医院.
- 通过过敏反应史和阳性过敏测试 (皮肤刺伤或特定IgE) 确认诊断.
主要成果:
- 41名儿童被诊断患有IgE介导的子过敏.
- 第一次反应的平均年龄:20个月; 80.5%的患者在第一次摄入时反应.
- 皮肤反应 (90.2%) 是最常见的;过敏反应发生在9.8%的患者中.
- 大多数患者患有其他食物过敏 (82.9%) 和先例的亚托皮 (90.2%).
- 在41名患者中,只有1人在随访期间产生了自然耐受性.
结论:
- 子过敏是一种重要的儿科食物过敏,尽管它相对罕见.
- 过敏反应是一种值得注意的并发症,大约在10个病例中发生1例.
- 子过敏似乎是一种持久性疾病,具有较低的自然耐受性发展率.
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