在高脂肪饮食的年轻和老年小鼠中,自愿运动诱导的骨肌肉反应
Yuji Kanazawa1, Kenichiro Miyahara1, Tatsuo Takahashi2
1Department of Physical Therapy, Hokuriku University, Kanazawa, JPN.
Cureus
|July 28, 2025
概括
在高脂肪饮食中自愿炼减少了体重,并提高了小鼠腿部肌肉中的线粒体活动. 然而,随着年龄的增长,肌肉变得.
科学领域:
- 运动生理学 运动生理学
- 衰老的研究研究.
- 代谢研究的研究.
背景情况:
- 老化和高脂肪饮食 (HFD) 会增加体重,并损害骨肌肉的质量.
- 自发性体力活动对HFD养的老年人的影响尚不清楚.
研究的目的:
- 为了检查自发的轮子运行如何影响体重,肌内脂肪和线粒体功能在年轻和老年小鼠在HFD.
主要方法:
- 年轻的 (14周) 和老的 (84周) 雄性小鼠被食HFD八周.
- 小鼠被分配到运动或久坐的组,测量包括体重,肌肉体重,肌肉纤维大小和线粒体活动 (SDH).
- 用Oil Red O染色来评估肌肉内的脂肪.
主要成果:
- 在这两个年龄组中,自愿运动减少了体重.
- 运动增加了胃角肌肌中酸脱酶 (SDH) 的活性,这表明线粒体功能得到了增强.
- 肌内脂肪在年轻小鼠中增加,但不是老年小鼠;肌底肌肉显示最小的变化.
结论:
- 在HFD上运行的自发轮子降低了体重,并增强了胃肌中的线粒体活动.
- 骨肌肉对炼的适应能力与脂肪代谢有关,随着年龄的增长而降低,因肌肉类型而异.
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