在高风险人群中,他类药物和运动的比较有效性:系统审查和网络元分析
Jia-Li Chen1, Jin-Tao Zhang1, Xue-Hui Li1
1School of Education, Beijing Sport University, Beijing, China.
Frontiers in cardiovascular medicine
|July 28, 2025
概括
高剂量的他类药物可以在高风险心血管疾病 (CVD) 患者中优化降低动脉硬性. 全身振动 (WBV) 是最重要的非药物干预措施,而间歇训练 (INT) 可以改善动脉硬和短期血压.
科学领域:
- 心血管医学 心血管医学
- 运动生理学 运动生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 动脉硬度 (AS) 是心血管疾病 (CVD) 风险的关键预测因素.
- 在高风险心血管疾病人群中减少AS的最佳干预措施尚不清楚.
- 本综述评估了针对AS和相关血液动力学指标的干预措施.
研究的目的:
- 为了比较各种干预措施在降低动脉硬度 (AS) 的有效性.
- 为高风险心血管疾病 (CVD) 群体确定最有效的干预措施.
- 分析脉冲波速度 (PWV),静缩血压 (SBP) 和静缩血压 (DBP) 的影响.
主要方法:
- 58个随机对照试验 (RCT) 的系统审查和随机效应网络元分析.
- 包括干预措施:全身振动 (WBV),他类药物 (STA),间歇训练 (INT),有氧运动 (AE),抵抗运动 (RT) 和联合训练 (CT).
- 评估结果:在符合美国体育医学学院 (ACSM) 对心血管疾病风险因素的标准的参与者中,PWV,SBP和DBP.
主要成果:
- 所有长期干预措施都显著降低了PWV (p < 0.001).
- WBV,INT和AE显著降低了SBP和DBP (p < 0.001). 这两种药物均有显著的降低 (p < 0.001).
- 高剂量的他类药物 (hSTA) 显示了最佳的PWV降低 (SUCRA=92.0);WBV显示了SBP (SUCRA=94.0) 和DBP (SUCRA=77.3) 的最高疗效.
结论:
- 高剂量的他类药物 (hSTA) 是降低高风险心血管疾病人群中AS的最佳选择.
- 全身振动 (WBV) 是AS的主要非药物干预措施.
- 间歇训练 (INT) 对AS和血压都有短期的好处.
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