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艾滋病毒感染者的持续性炎症激活. 参与动脉样硬化
Francisco Illanes-Álvarez1,2,3, Denisse Márquez-Ruiz1,2,3, Sara Cuesta-Sancho1,2,4
1Servicio de Medicina Interna, Hospital Universitario Puerta del Mar, Cádiz, Spain.
Frontiers in medicine
|July 28, 2025
概括
艾滋病毒感染者 (PLWH) 呈现较高的炎症和血小板标志物,与动脉样硬化有关. 心血管风险因素和炎症独立地影响PLWH的亚临床动脉样硬化.
科学领域:
- 心血管健康 心血管健康
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 在艾滋病毒感染者 (PLWH) 中观察到动脉样硬化患病率的增加.
- 艾滋病毒感染与慢性炎症和免疫失调有关.
- 亚临床动脉样硬化对PLWH构成重大健康风险.
研究的目的:
- 在PLWH中分析炎症,免疫,内皮,血小板和凝血参数.
- 调查这些标志物与亚临床动脉样硬化之间的关系.
- 确定影响PLWH动脉样硬化发展的因素.
主要方法:
- 该研究包括120个PLWH和30个未感染HIV的对照.
- 测量了炎症标记物 (IL-6,sCD163,hs-CRP) 的血清水平,NET衍生参数,激活的T淋巴细胞,内皮标记物 (E-selectin,VCAM-1),血小板标记物 (P-selectin,PF4) 和凝血标记物 (D-二次体).
- 在一小部分参与者中,使用 carotid Doppler 超声波评估亚临床动脉样硬化.
主要成果:
- 与对照人群相比,PLWH表现出高水平的IL-6,sCD163,抗核体抗体,激活的T淋巴细胞,血小板因子4和D-二次体.
- 带有动脉样硬化病变的PLWH具有更高的心血管风险得分 (REGICOR,ASCVD) 和IL-6水平.
- 确定了REGICOR评分和IL-6血清水平作为与动脉样硬化相关的独立因素.
结论:
- 在PLWH中长期控制病毒载量与炎症,免疫,血小板和凝固标志物增加有关.
- 在PLWH的亚临床动脉样硬化独立受到传统心血管风险因素和高度炎症激活的影响.
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