视觉肥胖的人类指标作为急性胰腺炎严重程度的预测指标
Kaier Gu1, Wenxuan Shang2, Dingzhou Wang3
1Department of Internal Medicine, Shaoxing Maternity and Child Health Care Hospital, Shaoxing, China.
Frontiers in medicine
|July 28, 2025
概括
早期评估急性胰腺炎 (AP) 的严重程度至关重要. 像内脏脂肪指数 (VAI) 和机器学习模型 (特别是XGBoost) 这样的内脏肥胖指标显示出准确,快速的风险分层的前景.
科学领域:
- 医学科学 医学科学 医学科学
- 临床研究 临床研究
- 数据科学在医学中的数据科学
背景情况:
- 现有的急性胰腺炎 (AP) 严重程度评分系统在及时性,复杂性和敏感性方面存在局限性.
- 传统的身体质量指数 (BMI) 不充分反映内脏脂肪,阻碍了准确的AP严重性评估.
- 人类测量指标的预测价值对于内脏肥胖在AP严重性跨不同的病因需要进一步调查.
研究的目的:
- 评估人类指标和临床评分系统对AP严重性的预测性表现.
- 开发和验证用于早期和准确的AP严重性评估的机器学习模型.
- 探索内脏肥胖指标在改善AP风险分层中的有用性.
主要方法:
- 629名AP患者的回顾性队列研究,将他们分为轻度 (MAP) 和中度严重/严重 (MSAP/SAP) 组.
- 使用后勤回归和ROC分析评估了11个人类指标和6个临床评分系统.
- 开发和验证6个机器学习模型,包括XGBoost,使用LASSO回归进行预测器选择.
主要成果:
- 九个人类指标和所有临床评分系统显示MAP和MSAP/SAP组之间存在显著差异.
- 内脏肥胖指数 (VAI) 在人类指标中显示出最高的预测AUC,超过了几项临床评分.
- 在验证组中,XGBoost模型获得了最高的AUC (0.878),表明性能优越.
结论:
- 内脏脂肪指数 (VAI),心脏代谢指数 (CMI),脂质积累产物 (LAP) 和腰部甘油三指数 (WTI) 是AP严重程度的独立预测指标.
- 结合VAI和临床变量,XGBoost模型为早期AP严重性评估提供了一个快速,具有成本效益的工具.
- 视觉肥胖指标和机器学习模型增强急性胰腺炎的早期风险分层.
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