在NAFLD患者中SIBO的发生率和特征
Shamim Naizr1, Zaigham Abbas2, Darayus P Gazder3
1Department of Gastroenterology and Hepatology, Dr. Ziauddin Hospital, Clifton Campus, Karachi, Pakistan.
Euroasian journal of hepato-gastroenterology
|July 28, 2025
概括
细肠细菌过度生长 (SIBO) 影响了巴基斯坦37%的非酒精性脂肪肝病 (NAFLD) 患者,特别是那些晚期肝病患者. 早期SIBO查和治疗对于管理NAFLD进展至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 越来越多地与小肠细菌过度生长 (SIBO) 有关.
- 关于巴基斯坦NAFLD患者中SIBO患病率的数据有限.
- 这项研究调查了卡拉奇一家三级医疗中心的NAFLD患者的SIBO.
研究的目的:
- 为了确定SIBO在NAFLD患者中的患病率.
- 在这个人群中描述SIBO,包括相关的症状和并发症.
- 探索SIBO与NAFLD严重程度之间的关系.
主要方法:
- 对65名通过FibroScan®诊断的NAFLD成年人的前性横截面研究.
- 使用葡萄糖气呼吸测试 (GHBT) 诊断的SIBO.
- 记录了人口统计,并发症,症状,肝硬度 (FibroScan®) 和受控衰减参数 (CAP) 评分.
主要成果:
- 在37%的NAFLD患者中存在SIBO,其中28%是无症状的.
- SIBO与增加的肝纤维化 (F3-F4) 和肥胖症 (S2-S3) 相关联.
- 在患有严重肝功能障碍的患者中,SIBO阳性比较高,并且与脂质不良症和刺激性肠综合征相关.
结论:
- 巴基斯坦的NAFLD患者中有很大一部分患有SIBO,特别是那些患有晚期肝病的人.
- 建议在NAFLD患者中进行SIBO查,以便及时诊断和干预.
- 有效的治疗,包括利法西明和益生菌,显著降低了SIBO阳性.
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