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孕产妇接触tribuyltin会改变女性生殖系统的发育

Rosiane Aparecida Miranda¹, Beatriz Souza da Silva¹, Iala Milene Bertasso¹

¹Laboratory of Endocrine Physiology, Institute of Biology Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

The Journal of endocrinology

|July 28, 2025

概括

孕产妇暴露于微 (TBT) 会对女性后代的卵巢造成持久损伤,导致荷尔蒙失衡和潜在的不孕症. 这种内分泌干扰剂会影响卵泡发育和卵巢功能,增加生殖障碍的风险.

科学领域:

环境毒理学环境毒理学
生殖生物学生殖生物学
内分泌学在内分泌学.

背景情况:

三乙烯 (TBT) 是一种持久性环境污染物,因其内分泌干扰作用而闻名.
母亲接触TBT可能会影响后代的发育和长期健康.
女性生殖功能障碍是TBT暴露的已知后果之一.

研究的目的:

调查孕期和哺乳期TBT暴露对雌性老鼠后代生殖系统的长期影响.
为了确定卵巢功能和激素特征的剂量和年龄相关的变化.
评估TBT对卵巢卵泡动态,细胞变化和炎症标志物的影响.

主要方法:

怀孕的Wistar大鼠从怀孕到哺乳期暴露于乙醇 (对照剂),TBT 100 ng/kg或TBT 1000 ng/kg.
产后21,45和180天的雌性后代被评估为生物识别,荷尔蒙,雌性循环和卵巢参数.
卵巢组织学,卵泡数,激素水平 (,FSH),雌激素受体α (ERα),雄激素受体 (AR) 和IL-6表达被分析.

主要成果:

暴露于TBT减少了出生体重和后来体重,改变了和FSH水平,并破坏了雌激素循环.
卵巢分析显示囊性/动性卵泡增加,原始卵泡和黄体体减少,纤维化.
结核病治疗暴露增加了ERα和AR表达,卵巢巨细胞和IL-6蛋白水平,表明炎症和受体变化.

结论:

孕产妇的TBT暴露会导致女性后代的卵巢发育和功能发生显著的,持久的干扰.
这些干扰包括改变的卵泡动态,荷尔蒙失衡和炎症,可能增加对PCOS和POI等疾病的易感性.
该研究强调了孕期和哺乳期的关键发育窗口,用于TBT的不良生殖效应.

关键词:

内分泌干扰的化学物质破坏性化学物质女性后代的后代是女性.母亲暴露的母亲暴露.致敬林林的人民

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