复原内镜用于治疗困难的胃肠道缺陷:试点试验的结果
Dania Nachira1, Valerio Pontecorvi2, Angelo Trivisonno3
1Department of General Thoracic Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.
Endoscopy
|July 28, 2025
概括
内镜流体血管分量注射有效治疗复杂的胃肠道缺陷. 自生脂肪组织管血管分量 (tSVFem) 促进组织再生,为耐火性胃肠道病变提供安全和有前途的治疗选择.
科学领域:
- 再生医学是一种再生医学.
- 胃肠病学 胃肠病学
- 内镜治疗药物 内镜治疗药物
背景情况:
- 带有纤维边缘的胃肠道缺陷抵抗传统的内镜治疗.
- 自主脂肪组织 (tSVFem) 的流体血管分量提供了再生潜力.
- 透视输送SsVFem是一种新的治疗方法.
研究的目的:
- 评估内镜输送的tsvfem治疗上下肠道缺陷的疗效和安全性.
- 评估完整的缺陷解决,治疗频率,不良事件和复发率.
- 探索SsVFem在涉及邻近器官的复杂缺陷中的实用性.
主要方法:
- 试点试验涉及30名耐火性胃肠道缺陷的患者.
- tSVFem来源于自身脂肪组织,经过加工,并通过内镜注射.
- 主要结果:完全解决缺陷;次要结果:安全性和复发性.
主要成果:
- 14/15食道缺陷解决 (10个注射后).
- 在1-4次注射后,直肠缺陷解决率为60%.
- 在涉及尿道和其他邻近器官的缺陷中观察到成功的治疗;没有不良事件或复发.
结论:
- 内透镜tsvfem注射是复杂的食道和直肠缺陷的可行治疗方法.
- 这种再生疗法对耐火性肠胃病变,包括与其他器官相邻的病变具有前景.
- 自主SVFem为复杂的肠道缺陷提供了一个安全的,再生的内镜治疗选择.
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