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泛米学人口概念的历史及其在当代人口遗传学中的遗产

Andy Walton¹, Alex Aylward², Mark G Thomas¹

¹UCL Genetics Institute, Genetics, Evolution and Environment, University College London, London, UK.

Annals of human genetics

|July 28, 2025

概括

对遗传学至关重要的泛微性人口概念,在自然界中很少见. 它的历史根源和数学便利性塑造了现代遗传学,但随着新数据的出现,它的实用性可能会下降.

科学领域:

人口遗传学人口遗传学
进化遗传学的进化遗传学
保护遗传学保护遗传学

背景情况:

全球性人口概念在遗传学中是基础的,但在现实中很少发生.
它的正式化被认为是在现代合成期间,但历史分析揭示了更早的根源.
基本主义思想影响了它融入进化思想,影响了当代遗传学.

研究的目的:

追踪泛美人口概念的历史发展和概念基础.
评估本质主义的持久遗产及其在现代遗传学中的应用上的数学便利性.
根据不断增加的基因组数据和不断发展的建模方法,评估泛米学模型的未来实用性.

主要方法:

进化思想和遗传学文献的历史分析.
泛美人口概念的起源和持久性的概念评估.
讨论对人类进化,保护和医学中的基因组数据解释的影响.

主要成果:

泛美主义概念的长寿源于数学方便及其在调和达尔文主义与本质主义中的早期作用.
尽管拒绝了本质主义,但它的影响仍然存在于人口遗传学假设和采样策略中.
该概念的实用性受到基因组数据的不断增长以及对连续空间模型的日益增长的需求的挑战.

结论:

全世界人口概念虽然具有历史意义和数学方便,但其根深蒂固于过时的本质主义思想中.
它的遗产继续影响当代遗传学,可能影响基因组数据的解释.
未来的基因组研究可能需要转向更复杂的模型,减少对泛基因假设的依赖.

关键词:

连续空间连续空间.通过距离隔离的隔离.现代合成现代合成泛米的种群是泛米的种群.人口遗传学人口遗传学人口建模的人口建模.人口思维的人口思维

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