在ADHD的症状特异性肠道微生物和代谢概况显示,SCFA缺乏是关键的致病机制
Xinyue Wang1, Ning Wang1, Teng Gao1
1National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Peking University Institute of Mental Health, Beijing, China.
Gut microbes
|July 28, 2025
概括
这项研究揭示了与注意力缺陷/多动症障碍 (ADHD) 症状相关的特定肠道细菌和代谢物. 在小鼠中恢复有益的细菌,如Lactobacillus sanfranciscensis改善了ADHD行为,突出了ADHD中肠-大脑轴的作用.
科学领域:
- 微生物组研究的研究.
- 神经科学是一个神经科学.
- 代谢学 代谢学 代谢学
背景情况:
- 肠道微生物群的改变与通过肠-大脑轴与注意力缺陷/多动症 (ADHD) 有关.
- 具体的微生物贡献者及其在ADHD中的机制仍然不清楚.
研究的目的:
- 描述与明显的ADHD症状相关的肠道微生物特征.
- 探索代谢物在肠道微生物群中的调解作用与ADHD症状关系.
- 在小鼠模型中使用便微生物群移植验证发现.
主要方法:
- 在94名多动症患者和94名对照人群中进行了枪支元基因组测序和便代谢学.
- 在三个ADHD症状子组中分析了微生物特征.
- 代谢建模,因果调解分析和小鼠便微生物群移植.
主要成果:
- ADHD症状与肠道微生物β多样性变化相关,特别是在综合的ADHD表现中.
- 包括Lactobacillus sanfranciscensis在内的有益细菌受到下调,并与核心ADHD症状有关.
- 伊米达酸部分调解了L. sanfranciscensis和注意力不集中之间的联系;用L. sanfranciscensis进行FMT可以改善小鼠的ADHD行为.
结论:
- 独特的ADHD症状与常见和特定的肠道微生物群和代谢物有关.
- 肠道微生物的组成会影响ADHD的症状,可能是通过代谢变化.
- 这项研究提供了对ADHD代谢障碍和肠道微生物组的作用的机制性见解.
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