相关实验视频

Updated: Sep 13, 2025

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers

Published on: January 5, 2018

治疗酒精依赖的数字治疗方法的有效性和安全性:一个多中心,开放标签,随机对照试验

Ryuhei So^1,2, Kazuhiro Nouso³, Sachio Matsushita⁴

¹CureApp, Inc., Tokyo, Japan.

Psychiatry and clinical neurosciences

|July 28, 2025

概括

一个数字治疗 (DTx) 应用程序ALM-003有效地减少了酒精依赖的个体的重度饮酒日. 该软件增强了心理社会干预,在随机对照试验中显示出显著的结果.

科学领域:

数字治疗学数字治疗学
行为科学是一种行为科学.
临床心理学临床心理学

背景情况:

数字疗法 (DTx) 提供了新的方法来增强心理社会干预.
ALM-003是一种DTx,旨在支持酒精依赖的个人,旨在减少饮酒.
该应用程序通过自我监测,个性化反和教育模块来促进行为变化.

研究的目的:

为了评估DTx ALM-003.3的有效性和安全性.
评估ALM-003在减少酒精依赖患者重度饮酒日 (HDD) 的有效性.
将ALM-003增强干预与使用基本应用程序的标准心理社会干预进行比较.

主要方法:

进行了一项多中心,开放标签,随机对照试验 (RCT).
具有高或非常高饮酒风险水平的参与者被随机分配到干预组 (ALM-003 + 心理干预) 或对照组 (基本应用 + 心理干预).
主要结局是从基线到第12周的28天重度饮酒日数的变化.

主要成果:

与对照组相比,干预组显示HDD的减少更大 (平均差异:-2.79天/28天;P=0.004).
基线HDD在两组之间是可比的 (19.4 vs 19.1天/28天).
不良事件发生率在各组之间相似 (32.9%与33.6%),没有事件归因于应用程序使用.

结论:

ALM-003是一种有效的数字治疗方法,可以减少酒精依赖的人的重度饮酒日数.
这项研究支持使用DTx来增强酒精使用障碍的治疗.
在本试验中,ALM-003显示出了良好的安全性.

关键词:

酒精依赖酒精依赖酒精依赖酒精使用障碍饮酒障碍数字治疗学数字治疗学沉重的饮酒沉重的饮酒移动应用程序移动应用程序

更多相关视频

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

相关概念视频

CNS Depressants: Alcohol and Nicotine

CNS Depressants: Alcohol and Nicotine

Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...