[唾液黑激素与牙周病之间的关联:系统性审查和元分析]
M A Gorbatova1, E A Mitkina1, L N Gorbatova1
1Northern State Medical University, Arkhangelsk, Russia.
概括
较低的唾液黑激素水平与牙周炎有关. 这一系统性审查和元分析强调了显著的变异性,表明需要进一步的研究来证实黑激素与牙疾病之间的关联.
科学领域:
- 口腔健康研究研究 口腔健康研究
- 内分泌学 在内分泌学.
- 生物标记分析 生物标记分析
背景情况:
- 牙周炎是一种流行的炎症性牙疾病.
- 黑激素是一种激素,在昼夜节律中起作用,具有抗炎性质.
- 黑激素水平的变化可能与各种健康状况有关.
研究的目的:
- 系统地审查和综合关于牙周炎患者与健康个体的唾液黑激素水平的科学证据.
- 进行牙周炎和唾液黑素之间的关联的定性和定量分析.
主要方法:
- 系统的文献搜索是按照PRISMA-2020指南进行的.
- 包括PubMed和eLibrary.Ru的出版物,其中20项研究被选中进行定性综合.
- 使用随机效应模型进行的元分析,使用科恩的d表示效应大小.
主要成果:
- 对20项研究 (2003-2023) 的元分析表明,与健康受试者相比,牙周炎患者的唾液黑激素水平显著降低 (总体效应-1.90).
- 少数研究 (10%) 在牙周炎患者中报告了更高的黑激素度.
- 在包括的研究中观察到高异质性 (I2=96.5%).
结论:
- 较低的唾液中黑激素度与牙周炎有关.
- 黑激素水平和研究效应的显著变化需要进一步调查.
- 建议以更大的样本大小进行未来的研究,以澄清这种关系.
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