基于2D矩阵阵列的3D引导LIFU的全新多功能系统
Steffen H Tretbar1,2, Marc Fournelle1, Christoph Risser1
1Department of Ultrasound, Fraunhofer Institute for Biomedical Engineering IBMT, Sulzbach, Germany.
这项研究引入了一种新的多功能系统,用于3D定向低强度聚焦超声波 (LIFU),用于非侵入性脑刺激. 该系统提供精确的准,灵活的时间模式生成和骨偏差校正,促进临床翻译.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 医疗器械 医疗器械
背景情况:
- 非侵入性脑刺激正在通过超声波技术进步.
- 低强度聚焦超声波 (LIFU) 提供精确的深度大脑准.
- 临床应用需要具有3D方向盘,灵活的时模式和头骨偏差校正的系统.
研究的目的:
- 为临床应用设计,制造和描述一个多功能3D引导的LIFU系统.
- 为了验证一个阶段偏差校正 (PAC) 算法用于头骨补偿.
- 评估系统是否符合医疗器械标准,并进行初始的MRI幻影研究.
主要方法:
- 开发一个2D矩阵阵列LIFU系统,用于3D光束方向和聚焦.
- 使用ex vivo头骨进行定制PAC算法的实施和验证.
- 测试医疗器械标准的符合性,并通过磁共振声波辐射力成像进行MRI幻影研究.
主要成果:
- 实现了3D光束方向和聚焦,侧焦尺寸降至4毫米,以实现精确的准.
- 证明了任意时间信号模式 (波形,脉冲长度,工作周期,升级) 的生成.
- 验证了头骨骨补偿的PAC算法,并在MRI研究中证实没有传感器工件.
结论:
- 开发的LIFU系统为超声神经调节提供了一个灵活的平台,平衡符合规范的和单元的设置.
- 该系统满足临床翻译的实际,技术,安全和监管要求.
- 这种多功能系统促进了研究,并有助于理解LIFU对神经刺激的影响.
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