怀孕和贝赫特综合征:一项意大利大型回顾性研究
Pietro Leccese1, Nancy Lascaro1, Assunta Iuliano2
1Rheumatology Department, San Carlo Hospital of Potenza, Potenza, Italy.
概括
在 Behçet 综合征 (BS) 患者的怀孕不会使疾病症状恶化或增加不良结果. 由于潜在的风险,特别是血管干扰,建议对BS的孕妇进行仔细的多学科随访.
科学领域:
- 类风湿病学 类风湿病学
- 产科和妇科 产科和妇科
- 免疫学 免疫学 免疫学
背景情况:
- 贝切特综合征 (BS) 是一种多因素的炎症性疾病,影响生育年龄的个体.
- 怀孕可以改变自身炎症和自身免疫性疾病中的免疫代谢状态,可能会影响疾病的过程和结果.
- 贝希特综合征与怀孕之间的关系需要进一步研究.
研究的目的:
- 为了调查贝希特综合征在怀孕期间爆发的患病率和临床特征.
- 为了评估一个大群意大利 Behçet 综合征患者的怀孕结果.
- 为了分析产后六个月的孕产妇和新生儿并发症.
主要方法:
- 从2000年1月到2021年12月,对贝希特综合征患者进行回顾性队列研究 (国际研究小组标准).
- 对人口统计,临床和与怀孕有关的数据的医疗记录的审查,包括疾病爆发和孕产妇/新生儿并发症.
- 数据收集包括母亲的年龄,怀孕期间和之后的疾病活动以及产后并发症.
主要成果:
- 疾病爆发发生在16.3%的怀孕中,主要是粘膜和关节的表现.
- 在17.6%的病例中,观察到产后发作,包括前性脑膜炎.
- 负面的妊娠结果包括流产 (17.6%),早产 (12.4%),先兆子 (3.9%),并兆子 (1.3%);没有报告新生儿并发症或死亡.
结论:
- 贝塞特综合征的临床症状似乎不会在怀孕期间恶化.
- 在BS患者中,怀孕与妊娠并发症的增加或对孕产妇和胎儿的不良结果无关.
- 多学科的妊娠后续检查对于管理潜在的不良事件,特别是血管干扰至关重要.
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