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Updated: Sep 13, 2025

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胃肠癌中微生物群驱动的表观遗传修饰:对病原和治疗策略的影响
Haniye Rahimi-Kolour1, Hedyeh Sadat Eshaghi1, Elahe Shams1
1Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
World journal of microbiology & biotechnology
|July 28, 2025
概括
肠道微生物群通过表观遗传变化影响肠道 (GI) 癌症. 针对这些微生物驱动的表观遗传通路,为癌症预防和治疗提供了新的策略.
科学领域:
- 微生物学 微生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 在瘤学瘤学.
背景情况:
- 胃肠道 (GI) 藏着对健康至关重要的复杂微生物群.
- 微生物失生症与各种疾病有关,包括胃肠道癌.
- 表观遗传修饰在癌症的发展中起着重要作用.
研究的目的:
- 审查肠道微生物群在驱动肠道癌症表观遗传修饰中的作用.
- 探索肠道微生物在表观遗传上影响宿主基因表达的机制.
- 突出针对肠道癌症管理的微生物群驱动的表观遗传途径的潜力.
主要方法:
- 现有科学文献的叙述性审查.
- 确定关键的细菌类和涉及胃肠道癌症表观遗传学的物种.
- 微生物代谢物的分析及其对表观遗传调节者的影响.
主要成果:
- 特定的细菌类 (Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria, Fusobacteria) 和物种 (例如,Fusobacterium nucleatum, Bacteroides fragilis) 都受到影响.
- 机制包括DNA甲基化,基因素修饰和非编码RNA调节.
- 微生物代谢物如SCFA和胆酸调节表观遗传酶.
结论:
- 肠道微生物群显著驱动肠道癌症的表观遗传变化.
- 微生物群衍生代谢物影响关键的表观遗传调节器.
- 针对微生物群与表观遗传相互作用,为胃肠道癌的预防和治疗提供了一个有希望的途径.
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