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胰岛素类生长因子-1作为查工具,以区分异形矮身和生长激素缺乏症之间的差异化

Vaman Khadilkar^1,2, Madhura Karguppikar^1,3, Aboli Bhalerao¹

¹Growth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, 411 001, India.

Indian journal of pediatrics

|July 28, 2025

概括

血清胰岛素样生长因子-1 (IGF-1) 有效地选儿童生长激素缺乏症 (GHD). 一个IGF-1Z-score切断值为-2.41,有助于区分GHD与异常性矮身 (ISS).

科学领域:

儿科内分泌学儿科内分泌学
生物化学标记物生物化学标记物
增长障碍发展障碍发展障碍

背景情况:

血清胰岛素样生长因子-1 (IGF-1) 测量是对生长激素缺乏症 (GHD) 的有价值的查工具,因为其日间变化最小.
区分GHD与异常性矮身 (ISS) 对于适当的治疗和管理至关重要.

研究的目的:

为了建立一个最佳的IGF-1 Z-分数切断界限,以区分儿童的GHD与ISS.
评估IGF-1在这个儿科群体中的诊断性能.

主要方法:

75名儿童的回顾性分析,包括38名GHD和37名ISS儿童.
在GHD和ISS组之间比较临床和生化参数,包括IGF-1度和Z分数.

主要成果:

与ISS患者相比,患有GHD的儿童体重,身高,BMI Z-score,骨龄与年龄的比率,IGF-1度和IGF-1 Z-score显著降低.
确定GHD与ISS区分的IGF-1Z得分最佳切线为-2.41,灵敏度为74.3%,特异性为89.2%.

结论:

在儿童中,IGF-1 Z-score为-2.41作为有效的切线来区分GHD和ISS.
在IGF-1水平明显高于这个切断值的情况下,应考虑像ISS这样的替代诊断,这可能会引导误诊患者的生长激素剂量调整.

关键词:

生长激素缺乏,生长激素缺乏.异常发病的矮身症患者.印度儿童印度儿童胰岛素类生长因子-1

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