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组胺调节Th1/Th2平衡,并通过CXCL9/CXCR3通路调节子宫内膜流体自

Ya Wen¹, Zexing Yang¹, Meng Rao¹

¹Department of Reproductive and Genetics, Kunming Medical University First Affilliated Hospital, Kunming, China.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

|July 28, 2025

概括

希斯胺通过激活CXCL9/CXCR3通路并抑制自而加剧子宫内粘附 (IUA) 和子宫内膜纤维化. 向组胺为IUA和纤维化提供了潜在的治疗策略.

科学领域:

生殖生物学生殖生物学
免疫学免疫学免疫学
细胞生物学细胞生物学

背景情况:

子宫内粘附 (IUA) 和子宫内膜纤维化是不孕不育的重要原因.
免疫调节剂胺与纤维性疾病有关,这表明它在IUA的发病过程中发挥了作用.

研究的目的:

研究组胺和TGF-β在IUA中调节CXCL9/CXCR3表达和自中的作用.
在IUA和子宫内膜纤维化中探索向组胺信号的治疗潜力.

主要方法:

在体外和体内实验使用子宫内膜细胞和IUA模型.
分析纤维化标记物 (α-SMA,Vimentin),自性标记物 (LC3B,p62),细胞因子和Th1/Th2两极分化通过西斑,qRT-PCR,IHC和流细胞计.
使用Mason和H&E染色的纤维化组织学评估.

主要成果:

TGF-β上调了CXCL9/CXCR3,增强了纤维化,并增加了自标志物.
通过激活CXCL9/CXCR3和抑制自流,胺增强了TGF-β的作用.
历史胺增加了促炎性细胞因子;HDC抑制减少了细胞因子和缓解了纤维化.
在IUA模型中,抑制CXCL9可改善血管生成并减少纤维化.

结论:

组胺通过CXCL9/CXCR3途径和受损的自流促进IUA进展.
向组胺或其信号通路为IUA和相关纤维状况提供了一个有希望的治疗途径.

关键词:

在CXCL9中使用.CXCR3CXCR3CXCR3CXCR3CXCR3CXCR3CXCR3CXCR3C Th1/Th2 的时间.自自是自的过程.基因组胺组胺的使用方法在子宫内粘附.

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