达尔巴万辛和β-乳酸胺之间对与内心炎相关的Enterococcus faecalis临床分离物的矛盾相互作用
David Luque Paz1,2, Adrien Turban2,3, François Guérin2,3,4
1Infectious Diseases Department, Pontchaillou University Hospital, Rennes, France.
The Journal of antimicrobial chemotherapy
|July 28, 2025
概括
达尔巴万辛对Enterococcus faecalis的活性较差,并且可以降低像阿莫西西林这样的β-乳酸盐的有效性. 建议在使用达尔巴万辛治疗E. faecalis感染,特别是内心炎时谨慎使用.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 有限的体外研究存在于达尔巴万辛与肠球菌的协同作用.
- Enterococcus faecalis 是一个重要的病原体,通常需要联合治疗.
研究的目的:
- 评估达尔巴万辛在体外对E. faecalis.alis的活性.
- 为了研究达尔巴万辛和β-乳糖抗生素之间的相互作用.
主要方法:
- 最低抑制度 (MIC) 和最小杀菌度 (MBC) 的确定.
- 对初始交互查的检查板测试.
- 时间杀伤 (TK) 测试以确认与β-乳糖胺的协同作用或对抗作用.
主要成果:
- E. faecalis菌株表现出对达尔巴万辛的耐受性 (MBC/MIC>32).
- 在TC试验中,在亚抑制度下观察到dalbavancin和β-lactams之间的协同作用.
- 当达尔巴万辛与阿莫西西林, ceftobiprole 或 ertapenem 在更高度下结合时,发现了对抗性,与单独的β-乳糖胺相比,显著减少了杀死细菌.
结论:
- 达尔巴万辛对E. faecalis. 的有效性有限.
- 达尔巴万辛可以降低β-乳酸盐的活性,尤其是阿莫西西林.
- 达尔巴万辛用于治疗E. faecalis感染性内心炎的临床使用,由于潜在的对抗作用,需要谨慎使用.
相关概念视频
Endocarditis III: Medical Management
19
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
19
Combined Effects of Drugs: Synergism
4.8K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
4.8K
Endocarditis II: Clinical Features of Infective Endocarditis
25
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
25
Endocarditis IV: Nursing Management
31
Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
31
Endocarditis I: Introduction
26
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
26
Antimicrobial Effectiveness
163
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
163


