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恶性黑色素瘤在抗PD-1治疗后转化为性神经细胞表型

Madison S Harris1, Claire Castaneda2, Aaron Wieland3

  • 1University of Wisconsin School of Medicine and Public Health, Madison, WI.

The American Journal of dermatopathology
|July 28, 2025
PubMed
概括

本病例报告详细介绍了一例罕见的皮肤黑色素瘤,在抗PD-1治疗后转化为性神经细胞表型. 它探讨了将这种转变与神经细胞起源和免疫检查点治疗联系起来的潜在机制.

关键词:
这是一种抗PD-1药物.没有分化,没有分化.关节性神经母细胞细胞发生了什么? 发生了什么? 发生了什么?免疫疗法 免疫疗法黑色素瘤是一种黑色素瘤.神经母细胞瘤的神经母细胞瘤类似神经母细胞瘤的表型这就是Pembrolizumab.通过转差异化转化.

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Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
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