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上脊髓半截切对隔膜神经运动控制的影响

Obaid U Khurram¹, Maximilian J Kantor-Gerber¹, Carlos B Mantilla^1,2

¹Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States.

Journal of neurophysiology

|July 28, 2025

概括

脊髓损伤 (C2SH) 改变了隔膜肌肉控制在每一侧的不同. 双侧神经驱动减少,减少运动单元的招募,而对侧驱动增加,增强招募.

科学领域:

神经科学是一个神经科学.
呼吸系统生理学呼吸系统生理学
脊髓损伤研究脊髓损伤研究

背景情况:

神经驱动到隔膜 (DIAm) 源于脑髓,并以ipsilateral 下降到神经发动神经元 (PhMN).
呼吸控制涉及运动单元 (MU) 的招募和退出,在脊髓损伤后可能会发生变化.

研究的目的:

为了研究C2脊柱半截切 (C2SH) 对膜肌 (DIAm) 的异侧和异侧神经运动控制的差异性影响.
评估C2SH后DIAm动力单元 (MU) 招聘和退聘的变化.

主要方法:

在C2SH之前和14天后,在清醒的老鼠中记录了双边DIAm电肌图 (EMG) 活动.
分析了EMG信号静止度,以估计MU招聘和退出招聘的持续时间.
在招聘和退聘阶段测量了DIAm EMG振幅.

主要成果:

C2SH 降低了 ipsilateral DIAm EMG 招募和峰值振幅,分别为 ~ 30% 和 ~ 35%.
C2SH增加了对应的DIAm EMG招募和峰值振幅,分别为70%和80%.
双边退聘幅度下降,而反边增加,暗示反边招聘更高门的MU.

结论:

C2SH对ipsilateral和contralateral DIAm神经运动控制有不同的影响.
在C2SH后失去ipsilateral神经驱动器导致减少ipsilateral DIAm MU招募.
增加的逆侧神经驱动器补偿了失去的ipsilateral驱动器,增强了逆侧DIAm MU的招募.

关键词:

在EMGEMGEMGEMGEMGEMGEMGEMGEMGEM 隔膜隔膜是一个隔膜.神经运动控制神经运动控制脊髓损伤导致的脊髓损伤静止性是一种静止性.

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