基于心肌细胞的多模式生物传感平台,用于动态功能评估生物启发的工程呼吸系统病毒诱导的心肌炎
Haote Han1,2,3, Ling Zou2, Jiaru Fang2,4
1Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
ACS nano
|July 28, 2025
概括
一个新的生物传感平台监测心脏细胞的电和活动,以检测病毒性心肌炎的早期迹象. 这项技术有助于了解心脏功能障碍,并选潜在的SARS-CoV-2感染等疾病的治疗方法.
科学领域:
- 心脏病学 心脏病学
- 病毒学 病毒学
- 生物医学工程 生物医学工程
背景情况:
- 呼吸系统病毒诱导的心肌炎 (RVIM) 是与流感和SARS相关的日益关注的问题,导致心律失常和心脏功能障碍.
- 目前的诊断方法缺乏灵敏度和分辨率,无法早期检测到微妙的心肌变化.
- 现有的方法很难捕捉动态的电生理学变化和细胞间变异.
研究的目的:
- 开发和验证用于早期检测RVIM的多式联络生物传感平台.
- 为了使心肌细胞的电和活动能够同时进行高分辨率的监测.
- 为研究病毒性心肌炎和查治疗提供临床前工具.
主要方法:
- 微电极阵列 (MEA) 电生理学与成像的整合.
- 同时,动态监测心肌细胞中的电活动和过渡物.
- 使用呼吸道病毒感染心肌细胞 (SARS-CoV-2,H1N1伪病毒) 的体外模型.
主要成果:
- 该平台检测到病毒感染心肌细胞中的异常电活动和过渡物.
- 这些异常表明刺激-收缩合有损.
- 尼菲迪平治疗证明了恢复受影响心肌细胞正常功能的能力.
结论:
- 多式联动生物传感平台为早期检测和监测RVIM提供了强大的临床前工具.
- 它有助于在细胞水平上研究呼吸道病毒相关的心肌功能障碍.
- 该平台支持高通量查和RVIM治疗反应的定量评估.
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