糖酸突变酶通过控制血清蛋白合成和单碳代谢来调节Treg分化

Wesley H Godfrey1, Judy J Lee1, Shruthi Shanmukha2

  • 1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States.

eLife
|July 28, 2025
PubMed
概括

糖酸盐突变酶 (PGAM) 通过控制血清蛋白合成来调节调节性T细胞 (Treg) 功能. 抑制PGAM或血清代谢会影响Treg分化和自身免疫性疾病,揭示新的治疗点.

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