在中年和老年患有慢性阻塞性肺病的中年和老年人中,生活必需的8分和抑郁症之间的非线性关联
Yushan Shi1,2, Di Huang1,3, Linlin Qu1
1Shandong University of Traditional Chinese Medicine, Jinan, China.
PloS one
|July 28, 2025
概括
更高的生活必需8 (LE8) 评分与慢性阻塞性肺部疾病 (COPD) 的成年人抑郁率较低有关. 保持良好的LE8得分,特别是50以上,可以显著降低患抑郁症的几率.
科学领域:
- 心血管健康 心血管健康
- 心理健康研究 心理健康研究
- 肺部医学 肺部医学
背景情况:
- 慢性阻塞性肺病 (COPD) 是一个重要的公共卫生问题.
- 抑郁症是COPD患者常见的并发症,影响生活质量和疾病管理.
- 生活必需品8 (LE8) 评分是对心血管健康的综合衡量标准,但其与COPD抑郁症的关联还未得到充分研究.
研究的目的:
- 为了研究生命的基本8 (LE8) 评分和患有COPD的40岁及以上成年人抑郁症的患病率之间的关联.
- 探索这种关系的性质,包括潜在的非线性效应和值点.
主要方法:
- 利用了2005-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 使用加权后勤回归和限制立方线 (RCS) 来分析LE8分数和抑郁症之间的相关性.
- 为了确定值效应,使用了两部分物流回归模型,并对强度进行了子组和灵敏度分析.
主要成果:
- 这项研究包括1110名COPD患者.
- 在LE8得分增加10个点与抑郁症的可能性降低有关 (OR:0.68).
- 观察到一种非线性关系,在LE8得分为50.0.0的转折点. 超过这一值的分数显示,抑郁症概率每点下降8.0% (OR:0.92).
- 较高的体力活动得分,减少尼古丁暴露,改善LE8的睡眠健康成分与较低的抑郁症患病率有关.
结论:
- 在COPD患者中,生命必需8分和抑郁症之间存在显著的非线性关联.
- 达到50.0或更高的LE8得分与此人群中抑郁症的几率相对较低有关.
- 这些发现强调了通过LE8指标促进心血管健康的重要性,以潜在地减轻COPD患者的抑郁症.
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