患有状细胞疾病的儿童的肺功能测试模式:一个病例对照研究
Abinaya Kannan1, Gaurav Sarnaik1, Nikita Agarwal1
1Department of Pediatrics, All India Institute of Medical Sciences, Tatiband, Raipur, Chhattisgarh, India.
PloS one
|July 28, 2025
概括
患有状细胞疾病 (SCD) 的儿童显示肺功能受损,包括较低的FEV1和FVC. 在这些儿童中,分量呼出的氧化 (FeNO) 水平与疾病严重程度没有相关性.
科学领域:
- 儿科肺病学 儿科肺病学
- 血液学 血液学 血液学
- 遗传性疾病 遗传性疾病
背景情况:
- 状细胞疾病 (SCD) 是一种遗传性疾病,与一种影响多个器官系统,包括肺部的亲炎症状态有关.
- 肺部并发症是SCD儿童的一个重大问题,影响他们的整体健康和生活质量.
研究的目的:
- 分析肺功能测试 (PFTs) 和SCD儿童的微分排气氧化 (FeNO) 水平.
- 为了比较患有SCD和健康对照儿童之间的PFT和FeNO水平.
- 调查与儿科SCD肺功能异常相关的因素.
主要方法:
- 一项涉及100名患有稳定SCD (6-20岁) 的儿童和100名年龄和身高匹配的健康对照的研究.
- 排除标准包括脊柱形,心肺呼吸系统症状和父母吸烟.
- 测量包括强制生命能力 (FVC),强制呼吸量在一秒内 (FEV1) 和分数呼出的氧化 (FeNO).
主要成果:
- 与对照组相比,患有SCD的儿童的FEV1,FVC,FEV1/FVC比率和PEFR显著降低 (所有儿童的p < 0.0001).
- 在患有SCD的儿童中,FeNO水平也明显较低 (p < 0.0001).
- 肺功能异常与年龄较小有关,而体重增加和更长的氨酸尿素持续时间与改善的PFT相关.
结论:
- 患有SCD的儿童经常出现限制性,阻塞性或混合性肺功能模式.
- 分数呼出的氧化 (FeNO) 含量与儿科SCD肺功能测试异常的严重程度没有相关性.
相关概念视频
01:25Pulmonary Function Tests
435
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
435
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.6K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.6K
01:47Lung Capacity
51.5K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
51.5K
01:19Factors Affecting Pulmonary Ventilation
1.6K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.6K