COVID-19和非COVID-19患者的血液感染之间的差异:单中心回顾性研究
Çağla Keskin Sarıtaş1, Halit Özsüt2, Aysun Benli2
1Department of Infectious Diseases and Clinical Microbiology, Marmara University Training and Research Hospital, Istanbul, Turkey.
Journal of infection in developing countries
|July 28, 2025
概括
患有重症监护室 (ICU) 相关血流感染 (BSI) 的COVID-19患者显示多药耐药 (MDR) 细菌的比率较高,与之前的抗生素使用有关. 与非COVID-19患者相比,这些患者在BSI后的生存时间较短.
科学领域:
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
- 微生物学 微生物学
背景情况:
- 在重症监护室 (ICU) 获得的血液感染 (BSI) 对患者的治疗结果构成重大威胁.
- 了解2019年冠状病毒病 (COVID-19) 患者中BSI的特定特征对于有效管理至关重要.
研究的目的:
- 为了比较COVID-19和非COVID-19患者与ICU获得的BSI的流行病学,临床,微生物学和结果数据.
- 确定与BSI患者死亡率相关的风险因素.
主要方法:
- 在2020年3月至2022年4月期间,对234名在ICU获得的BSI患者进行了回顾性研究.
- 患者被分为COVID-19 (n=127) 和非COVID-19 (n=107) 组.
- 使用描述性统计和后勤回归分析来比较群体并确定死亡风险因素.
主要成果:
- 在COVID-19患者中,BSI的呼吸道来源的发病率更高 (43.3%对26%).
- 在COVID-19患者中,Acinetobacter baumannii和格拉姆阴性多药耐药 (MDR) 细菌的患病率显著增加 (分别为24.4%与5.6%和81.7%与61.7%).
- 在COVID-19患者中,较长的先前抗生素使用与MDR格兰阴性细菌BSI有关,而COVID-19患者在BSI后的生存时间较短.
结论:
- 耐多药微生物在COVID-19患者中普遍存在,这些患者在ICU获得了BSI.
- 在医院中先前使用抗生素有助于COVID-19患者中MDR细菌BSI的发展.
- 在ICU获得的BSI患者中,COVID-19与较差的结果有关.
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