硫酸铜的环境相关度诱导了Labeo rohita中的生物化学和分子毒性

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Saima Naz¹, Riaz Hussain², Hafiz Muhammad Ali²

¹Department of Zoology, Government Sadiq College Women University, Bahawalpur, Pakistan.

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|July 28, 2025

概括

硫酸铜 (CuSO4) 暴露会在Labeo rohita中引起显著的氧化应激和DNA损伤. 这项研究表明,即使低度的CuSO4也是危险的,它会破坏鱼类的重要生理功能.

科学领域:

环境毒理学环境毒理学
水生毒理学水生毒理学
生物化学生物化学

背景情况:

铜对于生物催化是必不可少的,但在高水平时是有毒的.
过多的铜会引起氧化应激,并破坏生理过程.
了解水生生物中的铜毒性对于环境健康至关重要.

研究的目的:

为了研究不同度的硫酸铜 (CuSO4) 对Labeo rohita的毒理影响.
评估CuSO4暴露鱼的氧化应激,抗氧化酶活性和基因毒性.

主要方法:

拉贝奥罗希塔 (Labeo rohita) 在36天内接受了三次次致命剂量的CuSO4 (0.28,0.42,0.56μg/L).
使用微核和彗星测试来评估基因毒性.
氧化应激标志物 (ROS,TBARS) 和抗氧化酶活性 (SOD,POD,GSH,CAT) 在各种器官中被测量.

主要成果:

红细胞形态和核异常的显著增加被观察到.
高氧化应激参数 (ROS,TBARS) 和降低抗氧化酶活性发生在0.56μg/L CuSO4.
在淋巴细胞,大脑,肝脏和细胞中检测到显著的DNA损伤.

结论:

硫酸铜在Labeo rohita中诱导严重的生化和生理学障碍.
CuSO4对鱼类有害,即使在低度下,也会引起基因毒性和氧化应激.
这些发现凸显了水生生态系统中铜污染带来的环境风险.

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