用短波红外光打破联系:在900-1500nm NIR-II窗口中用于双光子激活的BODIPY光
Yagmur Aydogan-Sun1, Alexandra Egyed2, Arthur H Winter2
1Institute of Physical and Theoretical Chemistry, Goethe-University Frankfurt, Frankfurt am Main 60438, Germany.
Journal of the American Chemical Society
|July 28, 2025
概括
研究人员在近红外II (NIR-II) 窗口中使用双光子激发 (2PE) 开发了用于深层组织成像的新光. 这些基于BODIPY的分子可以在生物应用中有效释放光触发的货物.
科学领域:
- 摄影化学
- 有机化学
- 生物技术
背景情况:
- 光允许光触发的货物释放,但受到UV/可见刺激波长的限制,阻碍深层组织的透.
- 双光子激发 (2PE) 可实现近红外 (NIR) 或短波红外 (SWIR) 激活,提高组织透明度.
- 在第二个生物窗口 (1000-1350 nm) 中的光仍未得到充分探索.
研究的目的:
- 在NIR-II窗口应用中研究BODIPY光的二光子吸收 (2PA) 特性.
- 确定在900-1500nm范围内增强2PA的结构修改.
- 为生物成像和药物输送开发高效的2P可激活光驱器.
主要方法:
- 合成和表征了11个BODIPY光,在3位和5位进行了不同的替代.
- 在900-1500nm范围内测量了两光子吸收 (2PA) 截面 (δ).
- 对选定的化合物进行评估的量子产量和作用截面 (δΦu).
主要成果:
- 强大的电荷转移和增加的振动自由度显著增强了2PA.
- 达到高2PA截面:在900nm时超过4000GM (bis(styryl) -BODIPY) 和在1240nm时达到1110GM (单 styryl 模拟物).
- 合成的B-甲基化类似物,在900nm时具有高达5.8GM和在1300-1400nm时具有~1GM的脱作用.
结论:
- 在NIR-II窗口中确定了高效的2P可激活光驱动器的关键设计原则.
- BODIPY光可以设计为SWIR触发的货物释放,每光的能量最小.
- 这些发现为先进的生物应用铺平了道路,
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