婴儿早期的全身麻醉可以加速视觉皮层发育
Laurel J Gabard-Durnam1,2,3, Sarah A McCormick1, Ellen Underwood3,4,5
1Center for Cognitive and Brain Health, Northeastern University, Boston, MA 02120.
概括
重复的早期麻醉暴露加速了婴儿视觉唤起潜力 (VEP) 波形发育. 这表明GABA活性麻醉会影响早期大脑发育的保存机制,可能会影响具有刺激-抑制不平衡的婴儿.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 麻醉学 麻醉学
背景情况:
- 人类大脑发育涉及复杂的,漫长的轨迹.
- 抑制电路的成熟,如胺黄油酸 (GABA) 电路,对于皮质发育和动物模型中的关键时期至关重要.
- 早期功能抑制对人类大脑发育速度的影响尚不清楚.
研究的目的:
- 调查早期暴露于全身麻醉对人类婴儿大脑发育的影响.
- 为了确定GABA活性麻醉是否影响婴儿神经回路的发育轨迹.
- 探索与麻醉和大脑发育有关的跨物种潜在的保存生物机制.
主要方法:
- 一项涉及93名婴儿的纵向研究.
- 在早产后期重复暴露于全身麻醉.
- 视觉唤起潜力 (VEP) 波形及其延迟的评估.
主要成果:
- 暴露于重复全身麻醉的婴儿显示VEP波形的加速发展.
- VEP波形的延迟没有受到显著的影响.
- 观察到的加速表明受GABA活性麻醉影响的生物保护机制.
结论:
- 在婴儿期早期长时间接触GABA活性麻醉可以加速VEP波形发育.
- 这种效应可能特别适用于患有激发-抑制电路平衡变化的风险的婴儿.
- 研究结果表明,一种保存的跨物种机制将早期麻醉暴露与加速的神经成熟联系起来.
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